Pseudomonas aeruginosa, as many other bacteria (e.g., Staphylococcus aures, S.epidermidis), form more or less
maturated biofilms on the solid surfaces. The microbial cells growing in a biofilm are physiologically distinct from planktonic
cells of the same organism, which, by contrast, are single-cells that may float or swim in a liquid medium. Bacteria embedded
in biofilms are often difficult to eradicate with standard antibiotic regimens and inherently resistant to host immune responses.