When selecting an antibiotic for infections caused by Pseudomonas aeruginosa and Escherichia coli, it is essential to consider the spectrum of activity, pharmacodynamics, and the specific resistance patterns of the pathogens. The antibiotics tested in the image are potential treatment options for Escherichia coli infections, but the situation is different for P. aeruginosa.

• Cefoxitin is a second-generation cephalosporin and is not typically effective against P.aeruginosa (production of AmpC β-lactamase)
• Cefotaxim is a third-generation cephalosporin with limited activity against P. aeruginosa (production of AmpC β-lactamase)
• Gentamicin is an aminoglycoside with good activity against P. aeruginosa. However, it should be used in combination with a beta-lactam or beta-lactamase inhibitor for optimal effect
• Meropenem is a broad-spectrum carbapenem that has reliable activity against P. aeruginosa, including many multidrug-resistant strains (with the exception of carbapenemase-producing strains)
• Amikacin is an aminoglycoside that has strong activity against P. aeruginosa, particularly in cases of resistance to gentamicin and tobramycin
• Piperacillin/Tazobactam Activity gainst Pseudomonas aeruginosa: Good. Piperacillin is a broad-spectrum penicillin with activity against P. aeruginosa, and the addition of tazobactam (a beta-lactamase inhibitor) enhances its efficacy against beta-lactamase-producing organisms
• Tigecycline is a glycylcycline and does not have reliable activity against P. aeruginosa.

Best Choices for Pseudomonas aeruginosa Infections (in general):

• Meropenem, amikacin, and piperacillin/tazobactam are the most reliable options
• Gentamicin can be used in combination therapy for more severe infections



Interpretation of the Results

FOX	Cefoxitin	COX	Cefotaxime	GMN	Gentamicin	MEM	Meropenem
AKN	Amikacin	PTZ	Piperacillin/tazobactam	TGC	Tigecycline



Text generated with the help of OpenAI's language model, ChatGPT.